Nikon dropped big news at ASCB when they announced the development of two new super resolution microscopes. Two different technologies were announced, STORM and SIM.
The SIM technique was developed by Dr. Mats Gustaffsen, Dr. John Sedat and Dr. David Agard at UCSF. The technology doubles the XY resolution of a traditional CLSM, using a structured illuminations technique and custom manufacturing process. This method also supports 3-D sectioning as well as TIRF.
The STORM system was developed by Dr. Xiaowei Zhuang at Harvard University. This system uses statistical sampling of multiple exposures to produce extremely high resolution images. It supports 3-D image construction as well.
At the show floor Nikon had the A1R-MP Confocal system running. This system can perform very high frame rate acquisitions using multiphoton excitation.
Key features are:
- 420 fps with MP excitation
- Simple switching between resonant and non descanned detector systems. (done on the fly with no need to change hardware)
- Can be coupled with Plan Apo Water Immersion IR 60x lens
